It is said that her performance in the 2006 release Ankahee, received critical acknowledgement, and she continued it with a supporting character that she played in 2007 hit movie Bhool Bhulaiyaa. The actress has also endorsed famous Indian brands such as Bajaj Sevashram, Fair and Lovely, Cadburys Jai Lime, Fem, Lux, etc. After showing her brilliant acting skills in Anil Sharma’s Gadar: Ek Prem Katha, in 2002, she had four failures but her last suspense thriller, Humraaz, became one of the biggest grossing movies of the year at the box office,
and she was also nominated for Filmfare Best Actress Award for the film. The Abbas-Mustan marital thriller saw her enacting a role with negative shadows for the first time in in her career. Kya Yehi Pyaar Hai, Aap Mujhe Acche Lagne Lage were average box office success. Satish Kaushik's thriller film Vaada, featured Ameesha portraying the character of Arjun Rampal's disloyal wife. Elaan, showcased her as a TV reporter. She was also seen in Ketan Mehta's historical drama Mangal Pandey: The Rising. 2006 releases Mere Jeevan Saathi, Teesri Aankh: The Hidden Camera, Tathastu, Humko Tumse Pyaar Hai, etc were all big flops. 2011 projects Power, Run Bhola Run and Chatur Singh two Star featured the diva.